G. Patrick Meier

Associate Professor

Address

Fulmer 406
Pullman, WA 99164-4630

(509) 335-2637
email: meiergp@wsu.edu

Education

PhD Organic Chemistry, 1981
University of Wisconsin, Madison, WI

BA Chemistry, 1975
University of California, San Diego, CA

Research

Training: I received my BS degree from the University of California at San Diego in 1975, where I worked with Dr. Robert Fahey on biological significance of glutathione. I then went to the University of Wisconsin for my Graduate Studies. Here, I joined the research group of Dr. Edwin Vedejs and studied the mechanism of the Wittig Reaction and took part in developing a sulfur ylide based synthesis of Methynolide- a six man, 10 year project! After earning my Ph.D in 1981, I joined the research group of Dr. Larry Overman at the University of California at Irvine and help to develop a synthesis of Gelsemine, an alkaloid natural product. In 1985 I joined the faculty at the University of Washington (Seattle) in the Department of Medicinal Chemistry. In 1991, my wife (also an academician) and I moved to the Medical University of South Carolina, where I rose to the rank of Associate Professor. In August of 2003 I joined the faculty at the Washington State University in the Department of Chemistry.

Description of Research Program: The central focus of my research is the development of new methodology and approaches to the synthesis of organic compounds of biological interest. This focus, by virtue of its nature, requires that all projects have as a central focus the synthesis of a specific target and a secondary focus of the biological interest of the molecule explored. A significant aspect of our research is the extensive collaborative nature, especially with respect to the molecular biology, which encourages students in these projects to be well diversified in knowledge and techniques. Current projects include the synthesis and biological studies of analogs of xanthate and perillyl alcohol (a 'natural product') which both have anticancer activity, of biologically generated halo aromatics with potential for inducing metabolism of anthropogenic halo aromatics in some anaerobic organisms, and of small molecule inhibitors of ice crystal formation. Our program has been supported by the National Institutes of Health (NIH), National Science Foundation (NSF), and the Department of Defense (DoD).

Publications

Wu, Q., Meier, G. P., Sowers, K. R., May, H. D., "Dechlorination of chlorobenzenes by a culture containing bacterium DF-1, a PCB dechlorinating microorganism", Environ. Sci. Tech. 36:15, 3290-3294 (2002)

Morinelli, T. A., Meier, G. P., Webb, J. G., Jaffa, A. A., Privitera, P. J., Margolius, H. S., "Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable end product of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin)", International Immunopharmacology 2, 1995-2003 (2002)

Taylor, D. T., Halushka, P. V., Meier, G. P., "Hydrogen Bond Interactions in a Series of N-substituted Thromboxane A2 Receptor Antagonists", in revision for European Journal of Medicinal Chemistry

Vincent, T. S., Johnson, K. K., Re, G. G., Benich III, J. J., Meier, K. E., Meier, G. P., "Different Mechanisms for Growth Suppression of Prostate and Bladder Cancer Cells by Perillyl Alcohol and Perillaldehyde", in revision for Molecular Cancer Therapeutics

Worsencroft, K. J.; Kashlan, G.; Halushka, P. V.; Meier, G P., "Synthesis and Pharmacological Activity of Interphenylene Based Affinity Labels for the Thromboxane A2 Receptor", submitted to Bioorg. Med. Chem

Spencer, A. P., Hall, A. C., Meier, G. P. "Analysis of the Effects of Alpha-tocopherol on the Diagnostic Validity of Fecal Occult Blood Testing", submitted to Pharmacotherapy

Chemistry Department, PO Box 644630, Washington State University, Pullman WA 99164-4630, 509-335-5585, Contact Us

College of Sciences