ChulHee Kang

Professor of School of Molecular Biosciences

Director of Biomolecular Crystallography Center

Address

Fulmer 264
Pullman, WA 99164-4660
(509) 335-1409

email: chkang @wsu.edu
personal page: http://kang7.chem.wsu.edu/~kang

Education

BS, MS, Physics & Microbiology, 1982
Seoul National University, Seoul, Korea

PhD Biophysics, Chemistry, Biochemistry, 1987
University of California, Berkeley, CA

Postdoctoral Study, 1988-89
Lawrence Berkeley National Laboratory, Berkeley, CA

Postdoctoral Study, 1989-92
Massachusetts Institute of Technology, Cambridge, MA

Research

Cancer-related Projects

Intensive efforts are taking place to determine the structures of various cancer-associated proteins and types of damaged DNA, including oxidative and UV damaged, and, ultimately, to develop anticancer drugs. Using complex crystal structures and binding studies, the search for new anti-cancer drugs that are free of side effects, are being carried out. We are also investigating key plant enzymes involved in various pathways, which have important and direct connections with human health such as chemoprotection against various cancers, lowering blood cholesterol levels, and as antifungal/antiviral agents, biocides, antifeedants, and antioxidants. These studies will be used to develop treatments for various cancers and for prevention of certain allergies.

Antibiotics-related Projects

One of major challenges for modern medical research is the development of new antibiotics against pathogenic bacteria. We are trying to identify candidates for new antibiotic targets, which is of immense importance for the development of new generation antibiotics.

Publications

Kim, EJ, Tam, M, Siems, WF., & Kang C. (2005) Effects of the drugs with muscle-related side effects and affinity to calsequestrin on the calcium regulatory function of SR microsomes. J. Mol. Pharmacology [Epub ahead of print, doi:10.1124/mol.105.016253]

Tan, M-L, Kang C & Ichiye, T. (2005) The role of backbone stability near Ala44 in the high reduction potential class of rubredoxins Proteins (in press)

Youn, B, Moinuldin, GAS, Davin, LB, Lewis, NG & Kang, C. (2005) Crystal structures of apo-form, binary and ternary complexes of Podophyllum secoisolariciresinol dehydrogenase (SDH), an enzyme involved in formation of health-protecting lignans and in plant defense J.Biol.Chem. 280, 12917-12926.

Park, IY, Kim, E-J, Park, HJ, Fields, K., Dunker, KA., & Kang, C. (2005) Interaction Between Cardiac Calsequestrin and Drugs with Known Cardiotoxicity, J. Mol. Pharmacology 67, 95-105.

Rogers, SW, Youn, B, Rogers, JC, & Kang,C. (2004) Purification, Crystallization and Preliminary Crystallographic Studies of the Ligand Binding Domain of a Plant Vacuolar Sorting Receptor Acta Crystallographica D6 2028-2030.

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